Formulation Forum: Nanosuspension Dosage Forms
A typical nano-milling process and scale up equipment utilized by Ascendia.
Nano-formulation of poorly water-soluble drugs has brought two proven benefits to commercial drug products. One is it enhances drug dissolution and oral bioavailability. Second, nano-formulation increases drug loading and release duration for parenteral drug delivery. In the June issue of issue of Drug Development & Delivery, Ascendia Pharma CEO Jim Huang, Ph.D., discusses one method of preparing nanosuspensions in his Formulation Forum column.
Nano-formulation of poorly water-soluble drugs has been proven in commercial products to 1) enhance drug dissolution and oral bioavailability, and 2) increase drug loading and release duration for parenteral drug delivery. Preparation of drug nanosuspensions can be top-down, bottom-up, or a combination of both techniques. This month’s forum will focus on nanosuspensions prepared via the top-down process, ie, wet milling process.
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