Early development service for microbial fermentation

High throughput process development services for E. coli and yeast based on high degree of automation and digitalization to speed up time to clinic for diverse protein formats e.g., scaffolds, enzymes, pDNA, sub-unit vaccines and antibody fragments. Service description: - Genetic engineering, cell line and strain development for E.coli and Yeast hosts - High-density fermentation with E. coli expression systems - Soluble expression in E. coli with increased titers for Fabs - Inclusion body, refolding and HPLC both at clinical and commercial scale for purification steps - Caspon™ technology platform for purification - Half-life extension through chemical modifications, e.g. PEGylation - Proprietary plasmid DNA platform - AI-based modeling platform; machine-learning and integrated process modelling to derive best overall process