Daunorubicin 20830-81-3

20830-81-3

Similar to Doxorubicin, Daunorubicin interacts with DNA by intercalation and inhibition of macromolecularbiosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Daunomycin effectively binds to every 3 base pairs and induces a local unwinding angle of 11°, but negligible distortion of helical conformation.[5] It can also induce histone eviction from chromatin upon intercalation.

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CAS:20830-81-3

China

kilogram