Cevec’s CAPGo Derived Recombinant Placental Human Alkaline Phosphatase Shows Superior Results in a Preclinical Study

Cevec Pharmaceuticals has announced the results of a preclinical animal study in which its CAPGo derived recombinant placental human alkaline phosphatase (PLAP) showed significantly prolonged serum-half-life.

The company's glyco-optimized PLAP displayed a four times longer serum half-life in a pivotal rat study in comparison to an earlier recombinant version of the molecule. The new PLAP molecule originates from a newly developed cell line of Cevec's recently introduced CAPGO technology, which provides for specifically improved glycosylation patterns.

Today, various alkaline phosphatase (AP) isoforms are under development for the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis. In addition, chronic degenerative diseases such as Alzheimer's disease or Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) are being considered promising therapeutic indications for alkaline phosphatases. Currently, ongoing clinical trials are being conducted with purified proteins from either bovine intestinal tissues or with non-naturally occurring reassembled recombinant versions of these molecules. The molecule developed by Cevec, a recombinant wild-type version of a fully-human AP with a high, specific activity and a prolonged serum-half life, is expected to become the preferred alternative for these approaches.

The observed superior pharmacokinetic properties of CAPGo derived PLAP hold promise to affect the therapeutic efficacy of the molecule. This may lead to a reduction in effective dosage and frequency of administration; two important factors that pose a challenge in chronic indications. Together with the outstanding CAPGo production capabilities of up to 10 fold higher yields than conventional cell lines this new cell line enables the development of a highly efficacious and economic alkaline phosphatase based therapy. Cevec plans to partner the further development of the molecule.