Cara Therapeutics Completes Phase-I Study of Oral CR845
Cara Therapeutics has announced that phase-I trial results have provided a basis for further clinical development of its oral formulation of CR845.
Cara Therapeutics has completed its first phase-I clinical trial with an oral formulation of CR845, a peptide-based, peripherally-restricted kappa opioid receptor agonist.
An intravenous (IV) formulation of CR845 is currently being developed for the treatment of acute post-operative pain and it is hoped that an oral version can also be commercialised to treat ongoing pain following discharge from hospital.
The single-centre phase-I study aimed to assess the pharmacokinetics, safety and pharmacodynamics of CR845 in 50 healthy male volunteers.
Participants received one of four single ascending doses of orally available CR845 or a placebo.
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