BMS CheckMate -26 trial fails to meet primary endpoint
Opdivo did not meet trial primary endpoint of progression-free survival in patients expressing PD-L1 ≥ 5%.
Bristol-Myers Squibb Company (BMS) have announced that CheckMate -026, a trial investigating the use of Opdivo (nivolumab) as monotherapy, did not meet its primary endpoint of progression-free survival in patients with previously untreated advanced non-small cell lung cancer (NSCLC) whose tumors expressed PD-L1 at ≥ 5%. The company will complete a full evaluation of the CheckMate -026 data and work with investigators on the future presentation of the results.
Giovanni Caforio, CEO, Bristol-Myers Squibb, commented: “Opdivo has become a foundational treatment that is transforming cancer care across multiple tumour types. While we are disappointed CheckMate -026 did not meet its primary endpoint in this broad patient population, we remain committed to improving patient outcomes through our comprehensive development program, including the ongoing Phase 3 CheckMate -227 study exploring the potential of the combination of Opdivo plus Yervoy for PD-L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD-L1 negative patients.”
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