The Allegro Connect buffer management system provides buffer on demand. It is a flexible system designed for pilot scale, clinical batches and commercial production to ensure that the right buffer is delivered at the right time, providing an efficient, streamlined workflow. The modular system design enables up to six high volume process buffers to be supplied as required, one at a time, directly to the batch unit operation such as chromatography or tangential flow filtration (TFF) based on buffer inline-dilution (ILD) and utilizing a single-use flow path. Multi-column chromatography (MCC) application buffer requirements can also be met by the Allegro Connect buffer management system, delivering a maximum of four process buffers at the same time to the MCC chromatography system.