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Home Research & Development News ADDC and AstraZeneca announce third year of screening partnership
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10 Aug 2016

ADDC and AstraZeneca announce third year of screening partnership

Partnership facilitates efforts by researchers from academia to discover novel compounds with the potential to become new patient treatments.

The Academic Drug Discovery Consortium (ADDC) has announced the third call for proposals from its partnership with AstraZeneca. This partnership facilitates efforts by researchers from academia to discover novel compounds with the potential to become new patient treatments. This partnership provides ADDC members with access to high quality compound libraries and allows AstraZeneca the opportunity to collaborate with academic researchers to identify novel disease targets and drugs across different therapy areas.

The selected proposals will receive access to up to 250,000 compounds from AstraZeneca's internal screening libraries in addition to a small amount of funding. Three specific libraries are available for collaboration:

  • A 250,000 diversity set which provides a broad representation of AstraZeneca's industry-leading compound collection.

  • A 13,000 annotated set covering 1200 human targets with at least 100 nM potency at the primary target.

  • A low molecular weight fragment screening set of 17,000 compounds.

    • Proposals must be submitted by members of the ADDC and respond through the Request for Proposals (RFP) process. Responses will be judged by a Technical Review Committee consisting of AstraZeneca and ADDC members. AstraZeneca may provide financial or material support to selected projects.

    Seven proposals were selected over the last two years - hits from the first few screens are being evaluated for a follow-up collaboration.

    Additional information on this project, eligibility requirements, and the Call for Proposals can be found at www.addconsortium.org. Proposals are due Oct 31st, 2016. Proposals selected by the Review Committee will be announced in December 2016.

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