Improvements to PS80 Detection in Drug Product Formulations

A Mixed-Mode High-Performance Liquid Chromatography Method for the Determination of Polysorbates Offers Notable Improvements Over a Conventional Reverse Phase HPLC Method. We are presenting an innovative enhancement to the conventional reverse phase (RP) High Performance Liquid Chromatography (HPLC) method utilized for the analysis of polysorbates, including Polysorbate 80 (PS80).The new and improved approach to polysorbate analysis involves mixed-mode HPLC. Mixed-mode HPLC offers several advantages over the RP method, including reduced run times, improved signal resolution, minimal sample preparation, and decreased reliance on consumables. These enhancements not only improve data analysis, but also lead to substantial cost savings compared to the RP method, while also reducing the potential errors associated with extensive sample handling.